Catalytic Signature of a Heat-Stable, Chimeric Human Alkaline Phosphatase with Therapeutic Potential

Recombinant alkaline phosphatases are becoming promising protein therapeutics to prevent skeletal mineralization defects, inflammatory bowel diseases, and treat acute kidney injury. By substituting the flexible crown domain of human intestinal alkaline phosphatase (IAP) with that of the human placen...

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Main Authors: Kiffer-Moreira, Tina, Sheen, Campbell R., Gasque, Kellen Cristina da Silva, Bolean, Mayte, Ciancaglini, Pietro, van Elsas, Andrea, Hoylaerts, Marc F., Millán, José Luis
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933536/
https://ncbi.nlm.nih.gov/pubmed/24586729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089374
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