Catalytic Signature of a Heat-Stable, Chimeric Human Alkaline Phosphatase with Therapeutic Potential

Recombinant alkaline phosphatases are becoming promising protein therapeutics to prevent skeletal mineralization defects, inflammatory bowel diseases, and treat acute kidney injury. By substituting the flexible crown domain of human intestinal alkaline phosphatase (IAP) with that of the human placen...

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Hlavní autoři: Kiffer-Moreira, Tina, Sheen, Campbell R., Gasque, Kellen Cristina da Silva, Bolean, Mayte, Ciancaglini, Pietro, van Elsas, Andrea, Hoylaerts, Marc F., Millán, José Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933536/
https://ncbi.nlm.nih.gov/pubmed/24586729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089374
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