Catalytic Signature of a Heat-Stable, Chimeric Human Alkaline Phosphatase with Therapeutic Potential

Recombinant alkaline phosphatases are becoming promising protein therapeutics to prevent skeletal mineralization defects, inflammatory bowel diseases, and treat acute kidney injury. By substituting the flexible crown domain of human intestinal alkaline phosphatase (IAP) with that of the human placen...

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Autors principals: Kiffer-Moreira, Tina, Sheen, Campbell R., Gasque, Kellen Cristina da Silva, Bolean, Mayte, Ciancaglini, Pietro, van Elsas, Andrea, Hoylaerts, Marc F., Millán, José Luis
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933536/
https://ncbi.nlm.nih.gov/pubmed/24586729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089374
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