Φορτώνει......
Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl(−/−) mice by administration of soluble (non-targeted) chimeric alkaline phosphatase
Hypophosphatasia (HPP) results from ALPL gene mutations, which lead to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP), and accumulation of inorganic pyrophosphate, a potent inhibitor of mineralization that is also a natural substrate of TNAP, in the extracellular space. HPP causes mi...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Bone |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4283789/ https://ncbi.nlm.nih.gov/pubmed/25433339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.11.017 |
| Ετικέτες: |
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