Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl(−/−) mice by administration of soluble (non-targeted) chimeric alkaline phosphatase

Hypophosphatasia (HPP) results from ALPL gene mutations, which lead to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP), and accumulation of inorganic pyrophosphate, a potent inhibitor of mineralization that is also a natural substrate of TNAP, in the extracellular space. HPP causes mi...

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Publicado no:Bone
Main Authors: Gasque, Kellen, Foster, Brian L., Kuss, Pia, Yadav, Manisha C., Liu, Jin, Kiffer-Moreira, Tina, van Elsas, Andrea, Hatch, Nan, Somerman, Martha J., Millán, JoséLuis
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283789/
https://ncbi.nlm.nih.gov/pubmed/25433339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.11.017
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