Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia

Loss-of-function mutations in ALPL result in hypophosphatasia (HPP), an inborn error of metabolism that causes defective skeletal and dental mineralization. ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme expressed in bone, teeth, liver, and kidney that hydrolyzes the mineralization...

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Detalhes bibliográficos
Publicado no:J Dent Res
Main Authors: Foster, B.L., Kuss, P., Yadav, M.C., Kolli, T.N., Narisawa, S., Lukashova, L., Cory, E., Sah, R.L., Somerman, M.J., Millán, J.L.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347426/
https://ncbi.nlm.nih.gov/pubmed/27582029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0022034516663633
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