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Tissue-nonspecific Alkaline Phosphatase Deficiency Causes Abnormal Craniofacial Bone Development in the Alpl(−/−) Mouse Model of Infantile Hypophosphatasia

Tissue-nonspecific alkaline phosphatase (TNAP) is an enzyme present on the surface of mineralizing cells and their derived matrix vesicles that promotes hydroxyapatite crystal growth. Hypophosphatasia (HPP) is an inborn-error-of-metabolism that, dependent upon age of onset, features rickets or osteo...

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Detalhes bibliográficos
Main Authors: Liu, Jin, Nam, Hwa Kyung, Campbell, Cassie, Gasque, Kellen Cristina da Silva, Millán, José Luis, Hatch, Nan E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149826/
https://ncbi.nlm.nih.gov/pubmed/25014884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.06.040
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