Tissue Nonspecific Alkaline Phosphatase (TNAP) Regulates Cranial Base Growth and Synchondrosis Maturation

Hypophosphatasia is a rare heritable disorder caused by inactivating mutations in the gene (Alpl) that encodes tissue nonspecific alkaline phosphatase (TNAP). Hypophosphatasia with onset in infants and children can manifest as rickets. How TNAP deficiency leads to bone hypomineralization is well exp...

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Foilsithe in:Front Physiol
Main Authors: Nam, Hwa K., Sharma, Monika, Liu, Jin, Hatch, Nan E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2017
Ábhair:
Physiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359511/
https://ncbi.nlm.nih.gov/pubmed/28377728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00161
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