Tissue Nonspecific Alkaline Phosphatase (TNAP) Regulates Cranial Base Growth and Synchondrosis Maturation

Hypophosphatasia is a rare heritable disorder caused by inactivating mutations in the gene (Alpl) that encodes tissue nonspecific alkaline phosphatase (TNAP). Hypophosphatasia with onset in infants and children can manifest as rickets. How TNAP deficiency leads to bone hypomineralization is well exp...

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Опубликовано в: :Front Physiol
Главные авторы: Nam, Hwa K., Sharma, Monika, Liu, Jin, Hatch, Nan E.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2017
Предметы:
Physiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359511/
https://ncbi.nlm.nih.gov/pubmed/28377728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00161
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