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Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [(11)C]ABP688 and PET imaging study in depression

The mechanisms of action of the rapid antidepressant effects of ketamine, an NMDA glutamate receptor antagonist, have not been fully elucidated. This study examined effects of ketamine on ligand binding to a metabotropic glutamatergic receptor (mGluR5) in individuals with major depressive disorder (...

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Publicat a:Mol Psychiatry
Autors principals: Esterlis, Irina, DellaGioia, Nicole, Pietrzak, Robert H., Matuskey, David, Nabulsi, Nabeel, Abdallah, Chadi G., Yang, Jie, Pittenger, Christopher, Sanacora, Gerard, Krystal, John H., Parsey, Ramin V., Carson, Richard E., DeLorenzo, Christine
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636649/
https://ncbi.nlm.nih.gov/pubmed/28397841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.58
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