Imaging glutamate homeostasis in cocaine addiction with the mGluR5 PET radiotracer [(11)C]ABP688 and Magnetic Resonance Spectroscopy

BACKGROUND: Preclinical studies demonstrate that glutamate homeostasis in the striatum is disrupted following cocaine exposure, including a decrease in metabotropic glutamate receptor type 5 (mGluR5) expression and reduced glutamate turnover. The goal of this study was to use imaging of the human br...

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Detalhes bibliográficos
Main Authors: Martinez, Diana, Slifstein, Mark, Nabulsi, Nabeel, Grassetti, Alexander, Urban, Nina, Perez, Audrey, Liu, Fei, Lin, Shu-fei, Ropchan, Jim, Mao, Xiangling, Kegeles, Lawrence S., Shungu, Dikoma C., Carson, Richard E., Huang, Yiyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106018/
https://ncbi.nlm.nih.gov/pubmed/24035345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.06.026
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