Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [(11)C]ABP688 positron emission tomography

Nicotine addiction is a major public health problem, resulting in primary glutamatergic dysfunction. We measured the glutamate receptor binding in the human brain and provided direct evidence for the abnormal glutamate system in smokers. Because antagonism of the metabotropic glutamate receptor 5 (m...

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Main Authors: Akkus, Funda, Ametamey, Simon M., Treyer, Valerie, Burger, Cyrill, Johayem, Anass, Umbricht, Daniel, Gomez Mancilla, Baltazar, Sovago, Judit, Buck, Alfred, Hasler, Gregor
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545768/
https://ncbi.nlm.nih.gov/pubmed/23248277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210984110
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