Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [(11)C]ABP688 positron emission tomography

Nicotine addiction is a major public health problem, resulting in primary glutamatergic dysfunction. We measured the glutamate receptor binding in the human brain and provided direct evidence for the abnormal glutamate system in smokers. Because antagonism of the metabotropic glutamate receptor 5 (m...

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Detaylı Bibliyografya
Asıl Yazarlar: Akkus, Funda, Ametamey, Simon M., Treyer, Valerie, Burger, Cyrill, Johayem, Anass, Umbricht, Daniel, Gomez Mancilla, Baltazar, Sovago, Judit, Buck, Alfred, Hasler, Gregor
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545768/
https://ncbi.nlm.nih.gov/pubmed/23248277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210984110
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