Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [(11)C]ABP688 positron emission tomography

Nicotine addiction is a major public health problem, resulting in primary glutamatergic dysfunction. We measured the glutamate receptor binding in the human brain and provided direct evidence for the abnormal glutamate system in smokers. Because antagonism of the metabotropic glutamate receptor 5 (m...

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Detalhes bibliográficos
Main Authors: Akkus, Funda, Ametamey, Simon M., Treyer, Valerie, Burger, Cyrill, Johayem, Anass, Umbricht, Daniel, Gomez Mancilla, Baltazar, Sovago, Judit, Buck, Alfred, Hasler, Gregor
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545768/
https://ncbi.nlm.nih.gov/pubmed/23248277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210984110
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