Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [(11)C]ABP688 Positron Emission Tomography and Postmortem Study

OBJECTIVE: Clinical and preclinical evidence suggest a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been proposed as an attractive target for discovery of novel therapeutic approaches against depression. The goal of this study...

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Autori principali: Deschwanden, Alexandra, Karolewicz, Beata, Feyissa, Anteneh M., Treyer, Valerie, Ametamey, Simon M., Johayem, Anass, Burger, Cyrill, Auberson, Yves P., Sovago, Judit, Stockmeier, Craig A., Buck, Alfred, Hasler, Gregor
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129412/
https://ncbi.nlm.nih.gov/pubmed/21498461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2011.09111607
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