Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [(11)C]ABP688 positron emission tomography

Nicotine addiction is a major public health problem, resulting in primary glutamatergic dysfunction. We measured the glutamate receptor binding in the human brain and provided direct evidence for the abnormal glutamate system in smokers. Because antagonism of the metabotropic glutamate receptor 5 (m...

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Bibliografische gegevens
Hoofdauteurs: Akkus, Funda, Ametamey, Simon M., Treyer, Valerie, Burger, Cyrill, Johayem, Anass, Umbricht, Daniel, Gomez Mancilla, Baltazar, Sovago, Judit, Buck, Alfred, Hasler, Gregor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545768/
https://ncbi.nlm.nih.gov/pubmed/23248277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210984110
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