Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [(11)C]ABP688 and PET imaging study in depression

The mechanisms of action of the rapid antidepressant effects of ketamine, an NMDA glutamate receptor antagonist, have not been fully elucidated. This study examined effects of ketamine on ligand binding to a metabotropic glutamatergic receptor (mGluR5) in individuals with major depressive disorder (...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Esterlis, Irina, DellaGioia, Nicole, Pietrzak, Robert H., Matuskey, David, Nabulsi, Nabeel, Abdallah, Chadi G., Yang, Jie, Pittenger, Christopher, Sanacora, Gerard, Krystal, John H., Parsey, Ramin V., Carson, Richard E., DeLorenzo, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636649/
https://ncbi.nlm.nih.gov/pubmed/28397841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.58
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