In vivo ketamine-induced changes in [(11)C]ABP688 binding to metabotropic glutamate receptors subtype 5

BACKGROUND: At subanesthetic doses, ketamine, an N-Methyl-D-aspartate (NMDA) glutamate receptor antagonist, increases glutamate release. Here, we imaged the acute effect of ketamine on brain metabotropic glutamatergic receptors subtype 5 (mGluR5) with a high affinity PET ligand [(11)C]ABP688 ((E)-3-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biol Psychiatry
Prif Awduron: DeLorenzo, Christine, DellaGioia, Nicole, Bloch, Michael, Sanacora, Gerard, Nabulsi, Nabeel, Abdallah, Chadi, Yang, Jie, Wen, Ruofeng, Mann, J. John, Krystal, John H., Parsey, Ramin V., Carson, Richard E., Esterlis, Irina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277907/
https://ncbi.nlm.nih.gov/pubmed/25156701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.06.024
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