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Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer

KRAS is frequently mutated in lung cancers and is associated with aggressive biology and chemotherapy resistance. Therefore, innovative approaches are needed to treat these lung cancers. Prior work implicated the interferon-stimulated gene 15 (ISG15) deubiquitinase (DUB) USP18 as having anti-neoplas...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Cancer Res
Main Authors: Mustachio, Lisa Maria, Lu, Yun, Tafe, Laura J., Memoli, Vincent, Rodriguez-Canales, Jaime, Mino, Barbara, Villalobos, Pamela Andrea, Wistuba, Ignacio, Katayama, Hiroyuki, Hanash, Samir M., Roszik, Jason, Kawakami, Masanori, Cho, Kwang-jin, Hancock, John F., Chinyengetere, Fadzai, Hu, Shanhu, Liu, Xi, Freemantle, Sarah J., Dmitrovsky, Ethan
פורמט: Artigo
שפה:Inglês
יצא לאור: 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635999/
https://ncbi.nlm.nih.gov/pubmed/28242811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0369
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