Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice

Deubiquitinases are proteases with a wide functional diversity that profoundly impact multiple biological processes. Among them, the ubiquitin-specific protease 36 (USP36) has been implicated in the regulation of nucleolar activity. However, its functional relevance in vivo has not yet been fully de...

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發表在:J Biol Chem
Main Authors: Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Astudillo, Aurora, Vilarrasa-Blasi, Roser, Verdaguer-Dot, Nuria, Prado, Miguel A., Paulo, Joao A., Gygi, Steven P., Martín-Subero, José I., Freije, José M. P., López-Otín, Carlos
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2018
主題:
Protein Synthesis and Degradation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808777/
https://ncbi.nlm.nih.gov/pubmed/29273634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788430
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