USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer

KRAS is the most frequently mutated oncogene in human cancer, but its therapeutic targeting remains challenging. Here, we report a synthetic lethal screen with a library of deubiquitinases and identify USP39, which encodes an essential splicing factor, as a critical gene for the viability of KRAS-de...

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Publicat a:J Biol Chem
Autors principals: Fraile, Julia M., Manchado, Eusebio, Lujambio, Amaia, Quesada, Víctor, Campos-Iglesias, Diana, Webb, Thomas R., Lowe, Scott W., López-Otín, Carlos, Freije, José M. P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354494/
https://ncbi.nlm.nih.gov/pubmed/28154181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762757
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