Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

BACKGROUND: USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months of age. These tumors are leiomyosarcomas and thus represent a new murine model...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:BMC Cancer
Päätekijät: Chinyengetere, Fadzai, Sekula, David J., Lu, Yun, Giustini, Andrew J., Sanglikar, Aarti, Kawakami, Masanori, Ma, Tian, Burkett, Sandra S., Eisenberg, Burton L., Wells, Wendy A., Hoopes, Paul J., Demicco, Elizabeth G., Lazar, Alexander J, Torres, Keila E., Memoli, Vincent, Freemantle, Sarah J., Dmitrovsky, Ethan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640382/
https://ncbi.nlm.nih.gov/pubmed/26555296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1883-8
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