Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

BACKGROUND: USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months of age. These tumors are leiomyosarcomas and thus represent a new murine model...

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Bibliografiske detaljer
Udgivet i:	BMC Cancer
Main Authors:	Chinyengetere, Fadzai, Sekula, David J., Lu, Yun, Giustini, Andrew J., Sanglikar, Aarti, Kawakami, Masanori, Ma, Tian, Burkett, Sandra S., Eisenberg, Burton L., Wells, Wendy A., Hoopes, Paul J., Demicco, Elizabeth G., Lazar, Alexander J, Torres, Keila E., Memoli, Vincent, Freemantle, Sarah J., Dmitrovsky, Ethan
Format:	Artigo
Sprog:	Inglês
Udgivet:	BioMed Central 2015
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4640382/ https://ncbi.nlm.nih.gov/pubmed/26555296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1883-8
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Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

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