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Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas
BACKGROUND: USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months of age. These tumors are leiomyosarcomas and thus represent a new murine model...
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Publicado no: | BMC Cancer |
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Main Authors: | , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4640382/ https://ncbi.nlm.nih.gov/pubmed/26555296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1883-8 |
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