Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal transduction pathways emanating from KIT for tumorigenesis, the oncogenic Kit(V558Δ) mutation was combined with po...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bosbach, Benedikt, Rossi, Ferdinand, Yozgat, Yasemin, Loo, Jennifer, Zhang, Jennifer Q., Berrozpe, Georgina, Warpinski, Katherine, Ehlers, Imke, Veach, Darren, Kwok, Andrew, Manova, Katia, Antonescu, Cristina R., DeMatteo, Ronald P., Besmer, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635919/
https://ncbi.nlm.nih.gov/pubmed/28923937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711449114
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky