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Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor
Kit receptor-activating mutations are critical in the pathogenesis of gastrointestinal stromal tumors (GIST). We investigated mechanisms of oncogenic Kit signaling and the consequences of therapeutic intervention in a mouse model of human GIST. Treatment of GIST mice with imatinib decreased cell pro...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1568935/ https://ncbi.nlm.nih.gov/pubmed/16908864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511076103 |
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