Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor

Kit receptor-activating mutations are critical in the pathogenesis of gastrointestinal stromal tumors (GIST). We investigated mechanisms of oncogenic Kit signaling and the consequences of therapeutic intervention in a mouse model of human GIST. Treatment of GIST mice with imatinib decreased cell pro...

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Detalhes bibliográficos
Main Authors: Rossi, Ferdinand, Ehlers, Imke, Agosti, Valter, Socci, Nicholas D., Viale, Agnes, Sommer, Gunhild, Yozgat, Yasemin, Manova, Katia, Antonescu, Cristina R., Besmer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1568935/
https://ncbi.nlm.nih.gov/pubmed/16908864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511076103
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