Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal transduction pathways emanating from KIT for tumorigenesis, the oncogenic Kit(V558Δ) mutation was combined with po...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bosbach, Benedikt, Rossi, Ferdinand, Yozgat, Yasemin, Loo, Jennifer, Zhang, Jennifer Q., Berrozpe, Georgina, Warpinski, Katherine, Ehlers, Imke, Veach, Darren, Kwok, Andrew, Manova, Katia, Antonescu, Cristina R., DeMatteo, Ronald P., Besmer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635919/
https://ncbi.nlm.nih.gov/pubmed/28923937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711449114
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