Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase

Oncogenic Kit mutations are found in somatic gastrointestinal (GI) stromal tumors (GISTs) and mastocytosis. A mouse model for the study of constitutive activation of Kit in oncogenesis has been produced by a knock-in strategy introducing a Kit exon 11-activating mutation into the mouse genome based...

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Detalhes bibliográficos
Main Authors: Sommer, Gunhild, Agosti, Valter, Ehlers, Imke, Rossi, Ferdinand, Corbacioglu, Selim, Farkas, Judith, Moore, Malcolm, Manova, Katia, Antonescu, Cristina R., Besmer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164511/
https://ncbi.nlm.nih.gov/pubmed/12754375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1037763100
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