Imatinib resistance and microcytic erythrocytosis in a Kit(V558Δ;T669I/+) gatekeeper-mutant mouse model of gastrointestinal stromal tumor

Most gastrointestinal stromal tumors (GISTs) harbor a gain-of-function mutation in the Kit receptor. GIST patients treated with the tyrosine kinase inhibitor imatinib frequently develop imatinib resistance as a result of second-site Kit mutations. To investigate the consequences of second-site Kit m...

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Detalhes bibliográficos
Main Authors: Bosbach, Benedikt, Deshpande, Shayu, Rossi, Ferdinand, Shieh, Jae-Hung, Sommer, Gunhild, de Stanchina, Elisa, Veach, Darren R., Scandura, Joseph M., Manova-Todorova, Katia, Moore, Malcolm A. S., Antonescu, Cristina R., Besmer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427109/
https://ncbi.nlm.nih.gov/pubmed/22652566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115240109
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