KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion

The KIT receptor tyrosine kinase has important roles in hematopoiesis. We have recently produced a mouse model for imatinib resistant gastrointestinal stromal tumor (GIST) carrying the Kit(V558Δ) and Kit(T669I) (human KIT(T670I)) mutations found in imatinib-resistant GIST. The Kit(V558Δ;T669I/+) mic...

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Bibliographic Details
Main Authors: Deshpande, Shayu, Bosbach, Benedikt, Yozgat, Yasemin, Park, Christopher Y., Moore, Malcolm A.S., Besmer, Peter
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775897/
https://ncbi.nlm.nih.gov/pubmed/23681919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1419
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