Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure...

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書誌詳細
出版年:Cell Cycle
主要な著者: Wagner, Jessica, Kline, Christina Leah, Ralff, Marie D., Lev, Avital, Lulla, Amriti, Zhou, Lanlan, Olson, Gary L., Nallaganchu, Bhaskara Rao, Benes, Cyril H., Allen, Joshua E., Prabhu, Varun V., Stogniew, Martin, Oster, Wolfgang, El-Deiry, Wafik S.
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2017
主題:
Reports
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628644/
https://ncbi.nlm.nih.gov/pubmed/28489985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1325046
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