Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure...

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Gepubliceerd in:Cell Cycle
Hoofdauteurs: Wagner, Jessica, Kline, Christina Leah, Ralff, Marie D., Lev, Avital, Lulla, Amriti, Zhou, Lanlan, Olson, Gary L., Nallaganchu, Bhaskara Rao, Benes, Cyril H., Allen, Joshua E., Prabhu, Varun V., Stogniew, Martin, Oster, Wolfgang, El-Deiry, Wafik S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2017
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Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628644/
https://ncbi.nlm.nih.gov/pubmed/28489985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1325046
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