Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure...

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Wagner, Jessica, Kline, Christina Leah, Ralff, Marie D., Lev, Avital, Lulla, Amriti, Zhou, Lanlan, Olson, Gary L., Nallaganchu, Bhaskara Rao, Benes, Cyril H., Allen, Joshua E., Prabhu, Varun V., Stogniew, Martin, Oster, Wolfgang, El-Deiry, Wafik S.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628644/
https://ncbi.nlm.nih.gov/pubmed/28489985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1325046
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