Chaperone proteins as single component reagents to assess antibody nonspecificity

Early stage assays that evaluate monoclonal antibody drug-like properties serve as valuable tools for selection of lead candidates. One liability for clinical development, off-target reactivity, is often assessed by binding to a mixture or panel of noncognate proteins. While robust, these mixes are...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Kelly, Ryan L., Geoghegan, James C., Feldman, Jared, Jain, Tushar, Kauke, Monique, Le, Doris, Zhao, Jessie, Wittrup, K. Dane
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627595/
https://ncbi.nlm.nih.gov/pubmed/28745541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1356529
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