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Distinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Cα
Protein kinase Cα (PKCα) belongs to the family of AGC kinases that phosphorylate multiple peptide substrates. Although the consensus sequence motif has been identified and used to explain substrate specificity for PKCα, it does not inform the structural basis of substrate-binding and kinase activity...
Zapisane w:
| Wydane w: | J Biol Chem |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5625059/ https://ncbi.nlm.nih.gov/pubmed/28821615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.804781 |
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