Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric Mechanism

Protein kinases achieve substrate selective phosphorylation through their conformational flexibility and dynamic interaction with the substrate. Designing substrate selective or kinase selective small molecule inhibitors remains a challenge because of a lack of understanding of the dynamic mechanism...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Ma, Ning, Lippert, Lisa G., Devamani, Titu, Levy, Benjamin, Lee, Sangbae, Sandhu, Manbir, Vaidehi, Nagarajan, Sivaramakrishnan, Sivaraj
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432918/
https://ncbi.nlm.nih.gov/pubmed/30339352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00729
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