Distinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Cα

Protein kinase Cα (PKCα) belongs to the family of AGC kinases that phosphorylate multiple peptide substrates. Although the consensus sequence motif has been identified and used to explain substrate specificity for PKCα, it does not inform the structural basis of substrate-binding and kinase activity...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lee, Sangbae, Devamani, Titu, Song, Hyun Deok, Sandhu, Manbir, Larsen, Adrien, Sommese, Ruth, Jain, Abhinandan, Vaidehi, Nagarajan, Sivaramakrishnan, Sivaraj
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625059/
https://ncbi.nlm.nih.gov/pubmed/28821615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.804781
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