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Substrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency

The overlapping network of kinase-substrate interactions provides exquisite specificity in cell signaling pathways, but also presents challenges to our ability to understand the mechanistic basis of biological processes. Efforts to dissect kinase-substrate interactions have been particularly limited...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sommese, Ruth F., Sivaramakrishnan, Sivaraj
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063980/
https://ncbi.nlm.nih.gov/pubmed/27555323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737601
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