Dual Regulation of Diacylglycerol Kinase (DGK)-θ: POLYBASIC PROTEINS PROMOTE ACTIVATION BY PHOSPHOLIPIDS AND INCREASE SUBSTRATE AFFINITY

Diacylglycerol kinases are important mediators of lipid signaling cascades, and insight into their regulation is of increasing interest. Using purified DGK-θ, we show that this isoform is subject to dual regulation and that the previously characterized stimulation by acidic phospholipids is dependen...

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Bibliographic Details
Main Authors: Tu-Sekine, Becky, Raben, Daniel M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516713/
https://ncbi.nlm.nih.gov/pubmed/23091060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404855
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