Dual Regulation of Diacylglycerol Kinase (DGK)-θ: POLYBASIC PROTEINS PROMOTE ACTIVATION BY PHOSPHOLIPIDS AND INCREASE SUBSTRATE AFFINITY

Diacylglycerol kinases are important mediators of lipid signaling cascades, and insight into their regulation is of increasing interest. Using purified DGK-θ, we show that this isoform is subject to dual regulation and that the previously characterized stimulation by acidic phospholipids is dependen...

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Autors principals: Tu-Sekine, Becky, Raben, Daniel M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516713/
https://ncbi.nlm.nih.gov/pubmed/23091060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404855
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