IFITM3 requires an amphipathic helix for antiviral activity

Interferon‐induced transmembrane protein 3 (IFITM3) is a cellular factor that blocks virus fusion with cell membranes. IFITM3 has been suggested to alter membrane curvature and fluidity, though its exact mechanism of action is unclear. Using a bioinformatic approach, we predict IFITM3 secondary stru...

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Dettagli Bibliografici
Pubblicato in:EMBO Rep
Autori principali: Chesarino, Nicholas M, Compton, Alex A, McMichael, Temet M, Kenney, Adam D, Zhang, Lizhi, Soewarna, Victoria, Davis, Matthew, Schwartz, Olivier, Yount, Jacob S
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623871/
https://ncbi.nlm.nih.gov/pubmed/28835547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744100
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