The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity

Interferon-induced transmembrane protein 3 (IFITM3) is a cellular endosome- and lysosome-localized protein that restricts numerous virus infections. IFITM3 is activated by palmitoylation, a lipid posttranslational modification. Palmitoylation of proteins is primarily mediated by zinc finger DHHC dom...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: McMichael, Temet M., Zhang, Lizhi, Chemudupati, Mahesh, Hach, Jocelyn C., Kenney, Adam D., Hang, Howard C., Yount, Jacob S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766958/
https://ncbi.nlm.nih.gov/pubmed/29079573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.800482
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