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E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3

Interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cell-intrinsic factor that limits influenza virus infections. We previously showed that IFITM3 degradation is increased by its ubiquitination, though the ubiquitin ligase responsible for this modification remained elusive. Here, we demon...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Chesarino, Nicholas M., McMichael, Temet M., Yount, Jacob S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532365/
https://ncbi.nlm.nih.gov/pubmed/26263374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005095
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