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E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3

Interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cell-intrinsic factor that limits influenza virus infections. We previously showed that IFITM3 degradation is increased by its ubiquitination, though the ubiquitin ligase responsible for this modification remained elusive. Here, we demon...

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Pubblicato in:PLoS Pathog
Autori principali: Chesarino, Nicholas M., McMichael, Temet M., Yount, Jacob S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532365/
https://ncbi.nlm.nih.gov/pubmed/26263374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005095
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