Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts

Mitochondrial aprataxin (APTX) protects the mitochondrial genome from the consequence of ligase failure by removing the abortive ligation product, i.e. the 5′-adenylate (5′-AMP) group, during DNA replication and repair. In the absence of APTX activity, blocked base excision repair (BER) intermediate...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Çağlayan, Melike, Prasad, Rajendra, Krasich, Rachel, Longley, Matthew J., Kadoda, Kei, Tsuda, Masataka, Sasanuma, Hiroyuki, Takeda, Shunichi, Tano, Keizo, Copeland, William C., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622373/
https://ncbi.nlm.nih.gov/pubmed/28973450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx654
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