Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts

Mitochondrial aprataxin (APTX) protects the mitochondrial genome from the consequence of ligase failure by removing the abortive ligation product, i.e. the 5′-adenylate (5′-AMP) group, during DNA replication and repair. In the absence of APTX activity, blocked base excision repair (BER) intermediate...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Çağlayan, Melike, Prasad, Rajendra, Krasich, Rachel, Longley, Matthew J., Kadoda, Kei, Tsuda, Masataka, Sasanuma, Hiroyuki, Takeda, Shunichi, Tano, Keizo, Copeland, William C., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622373/
https://ncbi.nlm.nih.gov/pubmed/28973450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx654
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