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Role of pol β in complementing aprataxin deficiency during abasic site base excision repair
Pol β lyase removal of 5′-dRP from BER intermediates is critical in mammalian BER involving the abasic site. We found that pol β also removes 5′-adenylated dRP from BER intermediates after abortive ligation. The crystal structure of a pol β-DNA complex revealed that the 5′-AMP-dRP group is positione...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168318/ https://ncbi.nlm.nih.gov/pubmed/24777061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2818 |
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