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Role of pol β in complementing aprataxin deficiency during abasic site base excision repair
Pol β lyase removal of 5′-dRP from BER intermediates is critical in mammalian BER involving the abasic site. We found that pol β also removes 5′-adenylated dRP from BER intermediates after abortive ligation. The crystal structure of a pol β-DNA complex revealed that the 5′-AMP-dRP group is positione...
Gorde:
| Argitaratua izan da: | Nat Struct Mol Biol |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168318/ https://ncbi.nlm.nih.gov/pubmed/24777061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2818 |
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