Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand passage reactions. They involve passing one intact double stranded DNA duplex through a transient enzyme-bridged break in another (gated helix) followed by ligation of the break by TOP2. A TOP2 poison, etoposide blocks T...

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Bibliografische gegevens
Gepubliceerd in:Genes (Basel)
Hoofdauteurs: Morimoto, Suguru, Tsuda, Masataka, Bunch, Heeyoun, Sasanuma, Hiroyuki, Austin, Caroline, Takeda, Shunichi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
Onderwerpen:
Review
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895833/
https://ncbi.nlm.nih.gov/pubmed/31671674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10110868
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