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Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA
Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand passage reactions. They involve passing one intact double stranded DNA duplex through a transient enzyme-bridged break in another (gated helix) followed by ligation of the break by TOP2. A TOP2 poison, etoposide blocks T...
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| Publié dans: | Genes (Basel) |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6895833/ https://ncbi.nlm.nih.gov/pubmed/31671674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10110868 |
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