Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells

Metformin is a biguanide drug that is widely used in the treatment of diabetes. Epidemiological studies have indicated that metformin exhibits anti-cancer activity. However, the molecular mechanisms underlying this activity currently remain unclear. We hypothesized that metformin is cytotoxic in a t...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kadoda, Kei, Moriwaki, Takahito, Tsuda, Masataka, Sasanuma, Hiroyuki, Ishiai, Masamichi, Takata, Minoru, Ide, Hiroshi, Masunaga, Shin-ichiro, Takeda, Shunichi, Tano, Keizo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605006/
https://ncbi.nlm.nih.gov/pubmed/28926637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185141
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