SPA70 is a potent antagonist of human pregnane X receptor

Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70 is a potent and selective hPXR antagonist. SP...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lin, Wenwei, Wang, Yue-Ming, Chai, Sergio C., Lv, Lili, Zheng, Jie, Wu, Jing, Zhang, Qijun, Wang, Yong-Dong, Griffin, Patrick R., Chen, Taosheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622171/
https://ncbi.nlm.nih.gov/pubmed/28963450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00780-5
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