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High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor
Human pregnane X receptor (hPXR) is a nuclear receptor that regulates the expression of phase I and phase II drug-metabolism enzymes, as well as that of drug transporters. hPXR is a “xenobiotics sensor” and can be activated by structurally diverse compounds. The activation of hPXR by its agonists in...
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| Publicado no: | Assay Drug Dev Technol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5731549/ https://ncbi.nlm.nih.gov/pubmed/29112465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2017.809 |
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