High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor

Human pregnane X receptor (hPXR) is a nuclear receptor that regulates the expression of phase I and phase II drug-metabolism enzymes, as well as that of drug transporters. hPXR is a “xenobiotics sensor” and can be activated by structurally diverse compounds. The activation of hPXR by its agonists in...

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Bibliographic Details
Published in:Assay Drug Dev Technol
Main Authors: Lin, Wenwei, Goktug, Asli N., Wu, Jing, Currier, Duane G., Chen, Taosheng
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731549/
https://ncbi.nlm.nih.gov/pubmed/29112465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2017.809
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