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High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27(Kip1) Transcriptional Inhibitor

p27(Kip1) is a cell cycle inhibitor that prevents cyclin dependent kinase (CDK)/cyclin complexes from phosphorylating their targets. p27(Kip1) is a known tumor suppressor, as the germline loss of p27(Kip1) results in sporadic pituitary formation in aged rodents, and its presence in human cancers is...

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Detalhes bibliográficos
Main Authors: Walters, Brandon J., Lin, Wenwei, Diao, Shiyong, Brimble, Mark, Iconaru, Luigi I., Dearman, Jennifer, Goktug, Asli, Chen, Taosheng, Zuo, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960108/
https://ncbi.nlm.nih.gov/pubmed/24646893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091173
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