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High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27(Kip1) Transcriptional Inhibitor
p27(Kip1) is a cell cycle inhibitor that prevents cyclin dependent kinase (CDK)/cyclin complexes from phosphorylating their targets. p27(Kip1) is a known tumor suppressor, as the germline loss of p27(Kip1) results in sporadic pituitary formation in aged rodents, and its presence in human cancers is...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3960108/ https://ncbi.nlm.nih.gov/pubmed/24646893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091173 |
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