Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function

Cardiomyopathy frequently complicates sepsis and is associated with increased mortality. Increased cardiac oxidative stress and mitochondrial dysfunction have been observed during sepsis, but the mechanisms responsible for these abnormalities have not been determined. We hypothesized that NADPH oxid...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Joseph, Leroy C., Kokkinaki, Dimitra, Valenti, Mesele-Christina, Kim, Grace J., Barca, Emanuele, Tomar, Dhanendra, Hoffman, Nicholas E., Subramanyam, Prakash, Colecraft, Henry M., Hirano, Michio, Ratner, Adam J., Madesh, Muniswamy, Drosatos, Konstantinos, Morrow, John P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621873/
https://ncbi.nlm.nih.gov/pubmed/28878116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94248
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