Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function

Cardiomyopathy frequently complicates sepsis and is associated with increased mortality. Increased cardiac oxidative stress and mitochondrial dysfunction have been observed during sepsis, but the mechanisms responsible for these abnormalities have not been determined. We hypothesized that NADPH oxid...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Joseph, Leroy C., Kokkinaki, Dimitra, Valenti, Mesele-Christina, Kim, Grace J., Barca, Emanuele, Tomar, Dhanendra, Hoffman, Nicholas E., Subramanyam, Prakash, Colecraft, Henry M., Hirano, Michio, Ratner, Adam J., Madesh, Muniswamy, Drosatos, Konstantinos, Morrow, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621873/
https://ncbi.nlm.nih.gov/pubmed/28878116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94248
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