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A Modular Design for Minor Groove Binding and Recognition of Mixed Base Pair Sequences of DNA
The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full...
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| Publié dans: | Chem Commun (Camb) |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5616130/ https://ncbi.nlm.nih.gov/pubmed/28880316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc06246j |
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